NitrAdine® is a clinically proven, non-antibiotic formulation with disinfecting and pain reducing properties. It is the basis of multiple products manufactured and commercialized by bonyf. The NitrAdine® formulation has vast potential for additional product development.

Research and development are ongoing in the oral, wound care and general medical equipment disinfection areas (including veterinary) for both consumer and professional use.

NitrAdine® is bonyf’s proprietary formulation that was originally developed in 2001 to disinfect removable dentures that become quickly contaminated with pathogenic micro-organisms such as Candida albicans. 65% of people wearing dentures experience burning sensations, mucosal inflammation and discomfort in the mouth due to their contaminated denture. To ease this discomfort NitrAdine®-based cleaning and disinfecting effervescent tablets for dentures were developed.

As NitrAdine® removes Candida albicans and other pathogenic micro-organisms from both the surface and the microporosities of dentures successfully, additional NitrAdine® containing products were developed for disinfecting other removable oral appliances. These appliances include orthodontics, snoring and bruxism devices.

NitrAdine®’s uniqueness is due to its high efficacy in removing pathogenic biofilm from removable dentures, orthodontic appliances, toothbrushes, teeth, gums and dental implants. Multiple clinical studies have demonstrated its efficacy. It is safe to use and does not induce any side effects. By using NitrAdine® any potential tissue inflammation and pain caused by the presence of biofilm is significantly reduced, therefore restoring healthy mouth and gums.

NitrAdine® is not an antibiotic drug, nor a disinfecting molecule such as chlorhexidine, but a formulation of 9 chemical ingredients that interact resulting in its disinfecting and pain reducing properties.

The mode of action of NitrAdine®’s efficacy is based on the combined action of the formulation’s surfactant ingredient (Sodium lauryl sulphate) and the other ingredients. When NitrAdine® is dissolved in water (tablet formulation) or comes into contact with moisture (paste formulation), the surfactant disrupts the biofilm membrane proteins.

The interaction of the other ingredients results in a slow release of a non-toxic concentration of approx. 0.02% hypochlorite, killing micro-organisms (bacteria, yeast and viruses) present in the biofilm.

The NitrAdine® formulation has proven bactericidal, yeasticidal and virucidal properties and in addition induces a significant reduction of biofilm formed by a variety of disease inducing micro-organisms to clinically insignificant levels.

These include biofilms formed by (i) bacteria (Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa, Porphyromonas gingivalis, Provotella intermedia, Aggregatibacter actinomycetemcomitans); (ii) yeasts (Candida species); and (iii) viruses (Herpes simplex, Human Papilloma virus, Adenovirus, Poliovirus, Murine norovirus and all enveloped viruses (including Coronavirus).

Several independent academic pre-clinical and clinical studies have demonstrated NitrAdine®’s biofilm removal properties, consequently shifting any painful biofilm-induced tissue inflammation into a healthy healing state.

Biofilms are a collection of micro-organisms that are enclosed in a self-produced three-dimensional polysaccharide matrix that attaches and grows on many different surfaces.

Biofilms have antimicrobial drug resistance features and can be found on dentures, orthodontic appliances, teeth, gums, dental implants but also on toothbrushes.